蛋白质/抗原/多肽 >> 重组蛋白
重组Il11ra1蛋白
产品介绍 基因名: Il11ra1 产品别名: AI314697; GP130; Il-11ra; Il11ra; Il11ra2; NR1; Il11ra1; interleukin 11 receptor, alpha chain 1; interleukin 11 receptor, alpha chain 1; interleukin-11 receptor subunit alpha-1; IL-11 receptor subunit alpha-1; IL-11R subunit alpha-1; IL-11R-alpha-1; IL-11RA1; Il-11ra-alpha; NR-1; enhancer trap locus homolog 2; etl-2; interleukin 11 receptor, alpha chain 2; locus 2; novel cytokine receptor 1; 背景信息: Interleukin 11 receptor alpha (IL 11 R alpha, IL 11 R alpha 1) originally designated NR1 in mouse, is a 49 kDa type I transmembrane protein that is a member of the gp130 subfamily of the hematopoietic cytokine receptor family. IL-11 R alpha first binds IL 11 with low affinity, then forms a high affinity receptor when complexed with gp130 homodimers. IL 11 R alpha is also anti-apoptotic for colonic epithelia, and increased IL 11 signaling may be a factor in inflammation-associated gastrointestinal cancer development. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells. Essential for the normal development of craniofacial bones and teeth.A soluble form (sIL11RA) can act as an antagonist of IL11-dependent cell differentiation in cells where both transmembrane IL11RA and IL6ST are present. 标签:His-tag |
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