蛋白质/抗原/多肽 >> 重组蛋白
重组生长激素释放激素同源盒蛋白1
产品介绍 基因名: Gsx1 产品别名: Gsh-1; Gsh1; Gsx1; GS homeobox 1; GS homeobox 1; GS homeobox 1; genomic screened homeo box 1; homeobox protein GSH-1; 生长激素释放激素同源盒蛋白1; 背景信息: Growth hormone-releasing hormone (GHRH) stimulates secretion and synthesis of growth hormone (GH), causes somatotroph proliferation and may have direct actions in fetal/placental development, reproduction and immune function. It exerts its action through high-affinity GHRH receptors present in the anterior pituitary. GSH-1 (GS homeobox 1) is a 264 amino acid hypothalamic nuclear protein that functions as a transcription factor responsible for maintaining GHRH expression as well as playing an important role in pituitary development. Coexpression of CBP leads to significantly enhanced GSH-1-induced GHRH expression, which suggest that CBP may function as a co-activator. Knockdown of GSH-1 mRNA in mice causes a dwarf phenotype, which suggests that certain cases of familial dwarfism may be caused by a mutation of the GSH-1 gene. 标签:His-tag |
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