产品介绍 基因名： ARL6IP5 产品别名： DERP11； GTRAP3-18； HSPC127； JWA； PRAF3； Yip6b； addicsin； hp22； jmx； ARL6IP5； ADP ribosylation factor like GTPase 6 interacting protein 5； ADP ribosylation factor like GTPase 6 interacting protein 5； PRA1 family protein 3； ADP-ribosylation factor GTPase 6 interacting protein 5； ADP-ribosylation factor-like 6 interacting protein 5； ADP-ribosylation factor-like protein 6-interacting protein 5； ADP-ribosylation-like factor 6 interacting protein 5； ARL-6-interacting protein 5； JM5； PRA1 domain family 3； aip-5； cytoskeleton-related vitamin A-responsive protein； dermal papilla derived protein 11； glutamate transporter EAAC1-interacting protein； glutamate transporter EEAC1-associated protein； prenylated Rab acceptor protein 2； protein JWa； putative MAPK activating protein PM27； JWA蛋白； 背景信息： JWA is a four-transmembrane environmental responsive protein which binds to the CC chemokine recepor 5 (CCR5), a major co-receptor for human immunodeficiency virus (HIV). JWA is involved in environmental stress-responsive pathways in K562 cells, an erythroleukemia cell line derived from patients with chronic myeloid leukemia. Environmental stressors to K562 cells such as heat shock, a higher temperature than the ideal body temperature of the organism from which the cell line was derived, and oxidative stress, the production of oxygen-centered free radicals, regulate and increase the expres-sion of JWA. This response to environmental stressors suggests similiarity of JWA to heat shock protein 70 (HSP70), which is upregulated by heat stress and toxic chemicals. 标签：His-tag |
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