产品介绍 基因名： MED14 产品别名： CRSP150； CRSP2； CSRP； CXorf4； DRIP150； EXLM1； RGR1； TRAP170； MED14； mediator complex subunit 14； mediator complex subunit 14； mediator of RNA polymerase II transcription subunit 14； ARC150； CRSP complex subunit 2； RGR1 homolog； activator-recruited cofactor 150 kDa component； cofactor required for Sp1 transcriptional activation, subunit 2 (150kD)； hRGR1； human homolog of yeast RGR1； thyroid hormone receptor-associated protein complex 170 kDa component； thyroid hormone receptor-associated protein complex component TRAP170； transcriptional co-activator CRSP150； vitamin D receptor-interacting protein complex component DRIP150； vitamin D3 receptor-interacting protein complex 150 kDa component； 甲状腺受体相关蛋白CRSP2； 背景信息： The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein contains a bipartite nuclear localization signal. This gene is known to escape chromosome X-inactivation. [provided by RefSeq, Jul 2008] 标签：His-tag |
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