产品介绍 基因名： B4GALT2 产品别名： B4Gal-T2； B4Gal-T3； beta4Gal-T2； B4GALT2； beta-1,4-galactosyltransferase 2； beta-1,4-galactosyltransferase 2； beta-1,4-galactosyltransferase 2； N-acetyllactosamine synthase； UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 2； UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase 2； UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 2； UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 2； beta-1,4-GalTase 2； beta-4-GalT2； beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase 2； beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase； lactose synthase A protein； nal synthase； 背景信息： This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene synthesizes N-acetyllactosamine in glycolipids and glycoproteins. Its substrate specificity is affected by alpha-lactalbumin but it is not expressed in lactating mammary tissue. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2011] 标签：His-tag |
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