蛋白质/抗原/多肽 >> 重组蛋白
重组热休克因子结合蛋白1
产品介绍 基因名: HSBP1 产品别名: NPC-A-13; HSBP1; heat shock factor binding protein 1; heat shock factor binding protein 1; heat shock factor-binding protein 1; nasopharyngeal carcinoma-associated antigen 13; 热休克因子结合蛋白1; 背景信息: Prokaryotic and eukaryotic cells respond to thermal and chemical stress by inducing a group of genes collectively designated heat shock genes. In eukaryotes, this gene expression is regulated primarily at the transcription level. Heat shock transcription factors 1 and 2 (HSF1 and HSF2), also designated HSTF1 and HSTF2, are involved in this regulation and are upregulated by estrogen at both the mRNA and protein level. HSF1 is normally found as a monomer, whose transcriptional activity is repressed by constitutive phosphorylation. Upon activation, HSF1 forms trimers, gains DNA binding activity and is translocated to the nucleus. HSBP1 (heat shock factor-binding protein 1), also known as HSF1BP or NPC-A-13 (nasopharyngeal carcinoma-associated antigen 13), is a 76 amino acid nuclear protein that binds HSF1 and acts as a negative regulator of the heat shock response. 标签:His-tag |
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