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TRIAP1抗体
TRIAP1抗体图片
交货期: 1周
索取资料及报价
交货期:1周
产品别名:Anti-TRIAP1
Anti-TP53 regulated inhibitor of apoptosis 1 Antibody
产品介绍
靶标:

TRIAP1


产品别名:

HSPC132; MDM35; P53CSV; WF-1; TRIAP1; TP53 regulated inhibitor of apoptosis 1; TP53 regulated inhibitor of apoptosis 1; TP53-regulated inhibitor of apoptosis 1; mitochondrial distribution and morphology 35 homolog; p53-inducible cell-survival factor; protein 15E1.1;


背景信息:
TP53-regulated inhibitor of apoptosis 1 (TRIAP1, also known as p53 cell survival factor or p53CSV), is a small 76 amino acids long, evolutionarily conserved protein. TRIAP1 is a novel apoptosis inhibitor that binds HSP70 in the cytoplasm and blocks the formation of the apoptosome and caspase-9 activation. TRIAP1 is reported to be associated with resistance of apoptosis in different human malignancies. TRIAP1 is a pathway-specific regulator of the cellular response to p53 activation. Mechanistically, TRIAP1 modulates the apoptotic pathways through interaction with HSP70, inhibition of the interaction of cytochrome c with the apoptotic protease activating factor 1 and activation of the downstream caspase-9, thus resulting in increased resistance by inhibiting apoptosis and permitting DNA damage repair.

宿主:Rbt
类型:Pab
同种型:IgG  
应用:WB
纯化方式:亲和纯化
偶联物:Unconjugated
性状:液体
存储溶液:参阅说明书
浓度:Batch dependent (Please refer to the vial label for the specific concentration.)
稀释比例: Optimal dilutions/concentrations should be determined by the end user           
储存:经常使用则4°C保存。-20°C保存不超过两年。避免反复冻融。
注意事项:仅供实验室使用。不适用于人类或动物的任何临床,治疗或诊断用途。不适合动物或人类食用。

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