肌萎缩侧索硬化症相关蛋白HECW1抗体

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肌萎缩侧索硬化症相关蛋白HECW1抗体

交货期: 1周
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交货期:	1周
产品别名:	Anti-HECW1 Anti-HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 Antibody

产品介绍

靶标：

HECW1

产品别名：

NEDL1； HECW1； HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1； HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1； E3 ubiquitin-protein ligase HECW1； HECT type E3 ubiquitin ligase； HECT-type E3 ubiquitin transferase HECW1； NEDD4-like ubiquitin-protein ligase 1；肌萎缩侧索硬化症相关蛋白HECW1；

背景信息：

function:E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS.,pathway:Protein modification; protein ubiquitination.,similarity:Contains 1 C2 domain.,similarity:Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.,similarity:Contains 2 WW domains.,subunit:Interacts with DVL1 and SSR3. Also interacts with mutant SOD1.,tissue specificity:Predominantly expressed in neurons of adult and fetal brain. Weakly expressed in the kidney.,

宿主：Rbt
类型：Pab
同种型:IgG
应用：WB
纯化方式：亲和纯化
偶联物：Unconjugated
性状：液体
存储溶液：参阅说明书
浓度：Batch dependent (Please refer to the vial label for the specific concentration.)
稀释比例: Optimal dilutions/concentrations should be determined by the end user
储存：经常使用则4°C保存。-20°C保存不超过两年。避免反复冻融。
注意事项：仅供实验室使用。不适用于人类或动物的任何临床，治疗或诊断用途。不适合动物或人类食用。