产品介绍 靶标： GCN1 产品别名： GCN1L； GCN1L1； PRIC295； GCN1； GCN1 activator of EIF2AK4； GCN1 activator of EIF2AK4； eIF-2-alpha kinase activator GCN1； GCN1 (general control of amino-acid synthesis 1, yeast)-like 1； GCN1 eIF-2-alpha kinase activator homolog； GCN1 general control of amino-acid synthesis 1-like 1； GCN1, eIF2 alpha kinase activator homolog； GCN1-like protein 1； general control of amino-acid synthesis 1-like protein 1； hsGCN1； peroxisome proliferator activated receptor interacting complex protein； translational activator GCN1； 广泛控制氨基酸合成1样蛋白1； 背景信息： Acts as a positive activator of the EIF2AK4/GCN2 protein kinase activity in response to amino acid starvation. Forms a complex with EIF2AK4/GCN2 on translating ribosomes; during this process, GCN1 seems to act as a chaperone to facilitate delivery of uncharged tRNAs that enter the A site of ribosomes to the tRNA-binding domain of EIF2AK4/GCN2, and hence stimulating EIF2AK4/GCN2 kinase activity. Participates in the repression of global protein synthesis and in gene-specific mRNA translation activation, such as the transcriptional activator ATF4, by promoting the EIF2AK4/GCN2-mediated phosphorylation of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1 on 'Ser-52', and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion. 宿主：Rbt |
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