产品介绍 靶标: B4GALT6 产品别名: B4Gal-T6; beta4Gal-T6; B4GALT6; beta-1,4-galactosyltransferase 6; beta-1,4-galactosyltransferase 6; beta-1,4-galactosyltransferase 6; UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 6; UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6; UDP-Gal:glucosylceramide beta-1,4-galactosyltransferase; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 6; beta-1,4-GalTase 6; beta4GalT-VI; glucosylceramide beta-1,4-galactosyltransferase; lacCer synthase; lactosylceramide synthase; 背景信息: This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene is a lactosylceramide synthase important for glycolipid biosynthesis. [provided by RefSeq, Ju 宿主:Rbt |
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