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微管蛋白α3C(TUBa3C)抗体
产品介绍 靶标: TUBA3C 产品别名: TUBA2; bA408E5.3; TUBA3C; tubulin alpha 3c; tubulin alpha 3c; tubulin alpha-3C chain; Alpha-tubulin 3D; Tubulin alpha-3D chain; alpha-tubulin 2; alpha-tubulin 3C; alpha-tubulin 3C/D; tubulin alpha-2 chain; tubulin alpha-3C/D chain; tubulin, alpha 2; 微管蛋白α3C(TUBa3C); 背景信息: The class III type phosphoinositide 3-kinase (PI3KC3) / Vps34 regulates vacuolar trafficking as well as autophagy (1). UVRAG (UV radiation resistance-associated gene) is associated with the Beclin-1/PI3KC3 complex and promotes PI3KC3 enzymatic activity and autophagy, while suppressing proliferation (2). UVRAG is highly expressed in brain, lung, kidney and liver and contains one C2 domain, which is involved in calcium-dependent phospholipid binding. Beclin-1 binding to UVRAG promotes both autophagosome maturation and endocytic trafficking (3). UVRAG is also a potential tumor suppressor protein with frameshift mutations observed in colon and gastric carcinomas (4,5). 宿主:Rbt |
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