产品介绍 靶标: GYPB 产品别名: CD235b; GPB; GYP; GYPA; MNS; PAS-3; SS; GYPB; glycophorin B (MNS blood group); glycophorin B (MNS blood group); glycophorin-B; GYPB-A fusion; GYPB-A-B fusion; GYPB/GYPA fusion; SS-active sialoglycoprotein; Ss blood group; blood group system MNSs, Mur-like; blood group system MNSs, St(a) type E; blood group system MNSs, St(a) type F; glycophorin A; glycophorin B blood group antigen; glycophorin B, blood group system Ss, S, Mit+; glycophorin B/glycophorin A fusion protein; glycophorin Hop; hybrid glycophorin Kip; sialoglycoprotein delta; 血型糖蛋白δ; 背景信息: Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. GYPB gene consists of 5 exons and has 97% sequence homology with GYPA from the 5' UTR to the coding sequence encoding the first 45 amino acids. In addition to the M or N and S or s antigens, that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta; also, Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB. Alternate splicing results in multiple transcript variants. 宿主:Rbt |
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