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Rosiglitazone-d3
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Rosiglitazone-d3图片
CAS NO:1132641-22-5
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品名称
罗格列酮 d3
产品介绍
Rosiglitazone-d3 (BRL 49653-d3) 是 Rosiglitazone 的氘代物。Rosiglitazone (BRL 49653),是噻唑烷二酮类胰岛素增敏剂,也是选择性的,具有口服活性PPARγ激动剂,对 PPARγ1、PPARγ2 和 PPARγ 的EC50值分别为 30 nM、100 nM 和 60 nM。Rosiglitazone 与 PPARγ 结合,Kd约为 40 nM。Rosiglitazone 也是TRPC5的激活剂 (EC50=~30 μM) 和TRPM3的抑制剂。
生物活性

Rosiglitazone-d3 (BRL 49653-d3) is the deuterium labeled Rosiglitazone. Rosiglitazone (BRL 49653) is a selective, orally activePPARγagonist withEC50s of 30 nM, 100 nM and 60 nM for PPARγ1, PPARγ2, andPPARγ, respectively. Rosiglitazone binds toPPARγwith aKdof approximately 40 nM. Rosiglitazone is also an activator ofTRPC5(EC50=~30 μM) and an inhibitor ofTRPM3[1][2][3][4].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

分子量

360.45

Formula

C18H16D3N3O3S

CAS 号

1132641-22-5

中文名称

罗格列酮 d3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.