Aniline-MPB-amino-C3-PBD is a cytotoxic agent comprised non-alkylating group. Aniline-MPB-amino-C3-PBD is a sequence-selectiveDNAminor-groove binding agent. Aniline-MPB-amino-C3-PBD acts as the payload for ADCs. Antimicrobial activity^[1].

Aniline-MPB-amino-C3-PBD (compound 16) shows cytotoxicity with IC₅₀s of 77, 72, 79, 184.3, 61.5, and 145.6 nM for SW48, LIM1215, SW620, U138-MG, A431, and REH cells, respectively. Aniline-MPB-amino-C3-PBD effectively stabilises DNA with a degree of sequence-specificity. Aniline-MPB-amino-C3-PBD possesses potent anti-bacterial effects against the gram negative strainE. coliK12 with potency of 2 pg/mL determined^[1].

758.86

C₄₂H₄₆N₈O₆

2412923-79-4

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Please store the product under the recommended conditions in the Certificate of Analysis.