NITD-688 is an orally active pan-serotype inhibitor of the dengue virusNS4Bprotein. NITD-688 can be used in the research of dengue virus (DENV)^[1].

NS4B^[1]

NITD-688 shows antiviral activity against all four serotypes of dengue virus (DENV), with EC₅₀values of 8 to 38 nM^[1].
NITD-688 shows antiviral activity against DENV-2 infected PBMCs, with an EC₅₀value of 0.94 nM^[1].
NITD-688 directly binds to wild-type but not mutant NS4B protein^[1].

NITD-688 (30 mg/kg, oral gavage, twice daily for 3 days) demonstrates excellent antiviral efficacy in infected AG129 mice^[1].
NITD-688 (15-300 mg/kg, oral gavage, per day for 7 days) is well tolerated in rats and dogs (toxicology studies)^[1].

500.68

Solid

C₂₅H₃₂N₄O₃S₂

2407227-31-8

Room temperature in continental US; may vary elsewhere.

DMSO : 100 mg/mL(199.73 mM;ultrasonic and warming and heat to 60℃)

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。