GGTI-2166 is a geranylgeranyl transferase I inhibitor. GGTI-2166 inhibit the pOC formation induced by RANKL or TNF-alpha in cultures of both mouse marrow-derived macrophage-colony-stimulating factor (M-CSF) dependent monocytes (MD cells) and the mouse monocyte cell line RAW 264.7 (RAW cells). GGTI-2166 inhibited TRAP activity induced by RANKL or TNF-alpha in both cell cultures and prevented the incorporation of [3H]all-trans geranylgeraniol into prenylated proteins in RAW cells. References: Mulligan T, Farber SA. Central and C-terminal domains of heterotrimeric G protein gamma subunits differentially influence the signaling necessary for primordial germ cell migration. Cell Signal. 2011 Oct;23(10):1617-24. doi: 10.1016/j.cellsig.2011.05.015. Epub 2011 Jun 15. PubMed PMID: 21699975; PubMed Central PMCID: PMC3303753.

纯度：≥98%

CAS：478908-51-9