A metabolite of DPA with antiinflammatory properties
货号:ajcx21514
CAS:887752-13-8
分子式:C22H34O4
分子量：362.5
溶解度:DMF: 100 mg/ml,DMSO: 100 mg/ml,Ethanol: Miscible
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Novel oxylipins, referred to as docosanoids, have been derived from C₂₂polyunsaturated fatty acids 7(S),17(S)-dihydroxy-8(E),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic acid (7(S),17(S)-hydroxy DPA) is a DPA-derived analog of the 17(S)-dihydroxy series of docosanoids known as protectins. Protectin D₁, a DHA-derived dihydroxy fatty acid, exhibits potent anti-inflammatory activities.^1,2,3Potentially, 7(S),17(S)-hydroxy DPA demonstrates similar properties; however, its biological activity has yet to be determined.

1.Serhan, C.N., Gotlinger, K., Hong, S., et al.Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers: Assignments of dihydroxy-containing docosatrienesJ. Immunol.176(3)1848-1859(2006) 2.Ariel, A., and Serhan, C.N.Resolvins and protectins in the termination program of acute inflammationTRENDS in Immunology28(4)176-183(2007) 3.Schwab, J.M., Chiang, N., Arita, M., et al.Resolvin E1 and protectin D1 activate inflammation-resolution programmesNature447(7146)869-874(2007)