PDD 00017272 (34f) 是一种有效的 Poly(ADP-ribose) Glycohydrolase (PARG) 抑制剂，在生化试验和细胞 POM 中的 EC50 分别为 4.8 nM 和 9.2 nM。
货号:ajcx27948
CAS:1945950-20-8
分子式:C23H25N5O4S3
分子量：531.66
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Potent poly (ADP ribose) glycohydrolase (PARG) inhibitor (IC50 values are 4.8 nM in biochemical assay and 9.2 nM in cell based assay).

Waszkowycz et al (2018) Cell-active small molecule inhibitors of the DNA-damage repair enzyme poly(ADP-ribose) glycohydrolase (PARG): discovery and optimization of orally bioavailable quinazolinedione sulfonamides. J.Med.Chem. 61 10767 PMID:30403352