CN128是一种有口服活性、选择性的铁螯合剂(ironchelator)。CN128被用于β-地中海贫血的研究。
货号:ajcx30424
CAS:1335282-05-7
分子式:C15H18ClNO3
分子量：295.76
溶解度:Methanol: 5mg/mL,Methanol:PBS (pH 7.2) (1:1): 0.5mg/mL
纯度：98%
存储：Store at -20°C
库存：现货

Background:

CN128 is an orally active and selective iron chelator. CN128 is used for the research of β-thalassemia[1].

CN128 possesses a high selectivity for iron(III) over others metals[1].

CN128 (450 μmol/kg; p.o.) exhibits a good iron scavenging efficacy in rat[1].The iron removal efficacies of CN128 displays a dose-dependent behavior[1].CN128 lacks genetic toxicity[1].CN128 (75 μmol/kg; i.g.) possesses good oral bioavailability (82.6%), high maximal plasma concentration, and low clearance rats after an oral dose of 75 μmol/kg[1].CN128 is well-tolerated, with no mortality being observed at the higher dose levels in rats[1]. Animal Model: Male SD rats (300 g)[1]

[1]. Wenteng Chen, et al. CN128: A New Orally Active Hydroxypyridinone Iron Chelator. J Med Chem. 2020 Apr 23;63(8):4215-4226.