MDP1 acetate 是一种蜂毒肽 (melittin) 衍生肽，可改变革兰氏阳性和革兰氏阴性细菌膜的完整性，并通过膜损伤杀死细菌。MDP1 acetate 对金黄色葡萄球菌、大肠杆菌和铜绿假单胞菌的耐多药 (MDR) 和参考菌株具有很高的抗菌活性。
货号:ajcx39248
CAS:N/A
分子式:C113H206N34O30
分子量：2521.05
溶解度:H2O : 10 mg/mL (3.97 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

MDP1 acetate, a Melittin-derived peptide, alters the integrity of both Gram-positive and Gram-negative bacterial membranes and kills the bacteria via membrane damages. MDP1 acetate has a high-antibacterial activity against multidrug resistant (MDR) and reference strains of S. aureus, E. coli, and P. aeruginosa[1].

MDP1 acetate exhibits more potent antibacterial activities against S. aureus, E. coli and P. aeruginosa.Geometric means of MICs for MDP1 is recorded at 4.06 μg/mL (S. aureus), 1.22 μg/mL (E. coli) and 3.75 μg/mL (P. aeruginosa), respectively[1].DNA and calcein release and flow cytometry assays indicate a time-dependent antibacterial activity on the examined bacteria affected by MDP1 (10, 5, 2.5, 1.25, 0.625 and 0.312 μg/mL) acetate. Finally, SEM analyses highlights dose- and time-dependent effects of MDP1 acetate on S. aureus and E. coli bacteria by induction of vesicle or pore formation as well as cell lysis[1].

[1]. Akbari R, et al. Action mechanism of melittin-derived antimicrobial peptides, MDP1 and MDP2, de novo designed against multidrug resistant bacteria. Amino Acids. 2018;50(9):1231-1243.