A2ti-2 是选择性的，低亲和力的膜联蛋白 A2/S100A10 异四聚体 (A2t) 抑制剂，IC50 为 230 µM。A2ti-2 特异性破坏 A2 和 S100A10 之间的蛋白质相互作用。A2ti-2 可防止人乳头瘤病毒 16 型 (HPV16) 感染。
货号:ajcx32626
CAS:482646-13-9
分子式:C18H18N4O2S
分子量：354.43
溶解度:DMSO : 250 mg/mL (705.36 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

A2ti-2 is a selective and low-affinity annexin A2/S100A10 heterotetramer (A2t) inhibitor with an IC50 of 230 µM[1]. A2ti-2 specifically disrupts the protein-protein interaction (PPI) between A2 and S100A10. A2ti-2 prevents human papillomavirus type 16 (HPV16) infection[2].

A2ti-2 (compound 7a) is an annexin A2-S100A10 protein-protein interaction blocker[1]. A2ti-2 is less effective with<50% reduction in HPV16 PsV infection achieved at 100 µM. A2ti-1 decreases HPV16 entry with a 20% reduction at 100 µM[2].

参考文献:
[1]. Tummala R K Reddy, et al.Three-dimensional Pharmacophore Design and Biochemical Screening Identifies Substituted 1,2,4-triazoles as Inhibitors of the Annexin A2-S100A10 Protein Interaction. ChemMedChem. 2012 Aug;7(8):1435-46.
[2]. Andrew W Woodham, et al. Small Molecule Inhibitors of the Annexin A2 Heterotetramer Prevent Human Papillomavirus Type 16 Infection. J Antimicrob Chemother. 2015;70(6):1686-90.