EDANS(1,5-EDANS)是一种新型的淬灭荧光底物(fluorogenicsubstrate)，用于通过共振能量转移分析逆转录病毒蛋白酶。
货号:ajcx32404
CAS:50402-56-7
分子式:C12H14N2O3S
分子量：266.32
溶解度:DMSO: 13.89 mg/mL (52.16 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

EDANS (1,5-EDANS) is a novel and quenched fluorogenic substrate for assaying retroviral protease by resonance energy transfer (RET)[1].

The peptide sequence of EDANS is derived from a natural processing site for HIV-1 PR[1].Incubation of recombinant HIV-1 PR with the fluorogenic substrate resulted in specific cleavage at the Tyr-Pro bond and a time-dependent increase in fluorescence intensity that was linearly related to the extent of substrate hydrolysis[1].

[1]. E D Matayoshi, et al. Novel fluorogenic substrates for assaying retroviral proteases by resonance energy transfer. Science. 1990 Feb 23;247(4945):954-8.