YSK05 是一种对 pH 敏感的阳离子脂质。 YSK05 改善了非病毒载体的细胞内运输。 YSK05-MEND 显示出显着良好的基因沉默活性和溶血活性。 YSK05 克服了聚乙二醇化对内体逃逸的抑制。 YSK05 在体外和体内都有效地增强了 siRNA 的传递。
货号:ajcx28350
CAS:1318793-78-0
分子式:C42H77NO2
分子量：628.1
溶解度:Ethanol: 25 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

YSK05 is an ionizable amino lipid (apparent pK_a= ~6.5) that has been used in combination with other lipids in the formation of liposomes and lipid nanoparticles (LNPs).^1,2,3Administration of cyclic di-GMP in YSK05-containing liposomes increases serum levels of IFN-β, IFN-γ, IL-6, and TNF-α and activates natural killer (NK) cells in mice, as well as decreases lung metastasis in a B16/F10 murine melanoma model of metastasis.²Intravenous administration of factor VII siRNA in YSK05-containing LNPs reduces factor VII activity in isolated mouse plasma.³

1.Sato, Y., Hatakeyama, H., Sakurai, Y., et al.A pH-sensitive cationic lipid facilitates the delivery of liposomal siRNA and gene silencing activity in vitro and in vivoJ. Control. Release163(3)267-276(2012) 2.Nakamura, T., Miyabe, H., Hyodo, M., et al.Liposomes loaded with a STING pathway ligand, cyclic di-GMP, enhance cancer immunotherapy against metastatic melanomaJ. Control. Release216149-157(2015) 3.Sato, Y., Note, Y., Maeki, M., et al.Elucidation of the physicochemical properties and potency of siRNA-loaded small-sized lipid nanoparticles for siRNA deliveryJ. Control. Release22948-57(2016)