Inhibitor of β-(1,3)-D-glucan synthesis;fungicide
CAS：208538-73-2
分子式：C56H70N9NaO23S
分子量：1292.26
纯度：98%
存储：Store at -20°C

Background:

Micafungin is an antifungal agent [1].
Antifungal medicine is a pharmaceutical fungicide used to treat and prevent mycoses such as athlete's foot, ringworm, candidiasis (thrush), serious systemic infections such as cryptococcal meningitis, and others.
Micafungin is an antifungal agent known to inhibit 1,3-β-D-glucan synthesis in Candida albicans. In 13 out of 18 P. Aeruginosa isolates tested, micafungin significantly reduced biofilm biomass. In all 9 P. Aeruginosa isolates tested, micafungin decreased the expression of ndvB, which encoded the cell wall 1,3-β-D-glucan. Also, it decreased the expression of biofilm encoding genes for alginate and pellicles (algC and pelC, respectively) [1].
In a mouse model of septic A. fumigatus infection, micafungin (0.1 mg/kg) increased the survival rate of mice to 20%. When micafungin (0.1 mg/kg) combination with KB425796-C (32 mg/kg), the survival rate of mice increased to 100% in the 31-day post-infection period. While non-treated mice survived for only 6 days [2].
参考文献:
[1]. Bazzi W, Sabra A, Zahreddine L, et al. The inhibitory effect of micafungin on biofilm formation by Pseudomonas aeruginosa. Biofouling, 2013, 29(8): 909-915.
[2]. Kai H, Yamashita M, Nakamura I, et al. Synergistic antifungal activity of KB425796-C in combination with micafungin against Aspergillus fumigatus and its efficacy in murine infection models. J Antibiot (Tokyo), 2013, 66(8): 479-484.