Apoptotic agent-3 (compound 15f) 通过潜在的线粒体介导的 BCL-2/Bax 通路和激活 Caspase-3 途径促进凋亡。Apoptotic agent-3 具有抗增殖活性，可用于癌症研究。

Apoptotic agent-3 (compound 15f) promotes apoptosis through the potential mitochondria-mediated Bcl-2/Bax pathway and activation of the Caspase 3 pathway. Apoptotic agent-3 exhibits anti-proliferative activities and can be used for cancer research [1].

Apoptotic agent-3 (compound 15f) (24 hours) has selective anti-proliferative activities against HCT-116, HepG-2 MCF-7 and WI-38 cells (normal human cells) with IC 50 values of 1.62, 1.46, 2.04 and 117.9 μM, respectively [1].. Apoptotic agent-3 (compound 15f) (24 hours) (1.46 μM; 24 hours; HepG-2 cells) induces cell apoptosis, which increases the levels of active Caspase-3 and BAX by 11.53 folds and 10 folds, respectively, and decreases the level of Bcl-2 by 3.8 folds [1]. Cell Cycle Analysis [1] Cell Line: HepG-2 cells Concentration: 1.46 μM Incubation Time: 24 hours Result: The percentage of cells in the G2-M phase increased while the percentage of cells in G1 phase and S phase decreased. Apoptosis Analysis [1] Cell Line: HepG-2 cells Concentration: 1.46 μM Incubation Time: 24 hours Result: Increased the early apoptosis ratio from 0.69% to 8.25% and increased the late apoptosis ratio from 0.32% to 13.05%.

2482310-23-4

C31H21N5OS

511.6

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years