Fmoc-Thr[GalNAc(Ac)3-α-D]-OH 是制备基于三聚体 MUC1 免疫显性基序抗原的候选抗癌疫苗的起始材料，可制备含有 βGalNAc-?Thr 作为 Tn 抗原异构体的合成 MUC1 糖肽，可诱导针对肿瘤细胞的抗体产生。

Fmoc-Thr[GalNAc(Ac)3-α-D]-OH is a reagent for the preparation of a synthetic MUC1 Glycopeptide Bearing βGalNAc-Thr as a Tn antigen isomer which induces the antibody production against tumor cells. Fmoc-Thr[GalNAc(Ac)3-α-D]-OH is a starting material to make trimeric MUC1 immunodominant motif antigen-based anti-cancer vaccine candidates.

The Tn antigen is a tumor-associated carbohydrate antigen that is not normally expressed in peripheral tissues or blood cells. Expression of this antigen, which is found in a majority of human carcinomas of all types, arises from a blockage in the normal O-glycosylation pathway in which glycans are extended from the common precursor GalNAcα1-O-Ser/Thr (Tn antigen)[1].

116783-35-8

C33H38N2O13

670.66

Fmoc-Thr(Ac3AcNH-α-Gal)-OH;Fmoc-Thr[GalNAc(Ac)3-α-D]-OH;ZINC77292789

H2O:soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years